New Publication in MethodsX on the Quantification of Guanidine in Environmental Matrices.

27.09.2024

Recent discoveries have raised interest in the biological and environmental role of guanidine – a small, nitrogen-rich compound. Because little is known about the concentrations of guanidine in environmental compartments, a sensitive and selective method for guanidine quantification is needed.

This study led by Richard Gruseck and Michael Zumstein, with contributions from Thilo Hofmann, Marton Palatinsky, and Michael Wagner, focused on the further development and adaptation of an existing method to quantify guanidine. The resulting method, which is based on derivatization and LC-MS analysis, enables guanidine detection at concentrations in the range of 10 nanomolar and is applicable to human urine, wastewater, different biological growth media, and samples from other environments. This publication complements the recent Nature article on the "Growth of complete ammonia oxidizers on guanidine".

 

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